Pharmacokinetics and thrombolytic effects of the recombinant tissue-type plasminogen activator in horses
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چکیده
منابع مشابه
Pharmacokinetics and thrombolytic effects of the recombinant tissue-type plasminogen activator in horses
BACKGROUND To test the efficacy of the recombinant tissue-type plasminogen activator (rt-PA) alteplase in horses, the thrombolytic effect was tested in in vitro generated equine thrombi. The extent of lysis was determined by measuring the decrease in thrombi weight over a period of 4 hours. In vivo pharmacokinetics of alteplase were determined in 6 healthy horses. A single dose (1 mg/kg) was ap...
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ژورنال
عنوان ژورنال: BMC Veterinary Research
سال: 2013
ISSN: 1746-6148
DOI: 10.1186/1746-6148-9-158